What Should I Tell Doctors When I Order Fioricet online ?

There is a very long health questionnaires you should answer when you order fioricet online. It includes almost all aspects of your health condition, medical conditions, and you any kinds of diseases. It includes:

1. your sex
2. your weight;
3. your height
4. your BMI will be calculated according to your weight and your height;
5. why you order or buy fioricet online ?
6. your health conditions;
7. your medical conditions;
8. your health history;
9. your family health history;
10. your family medical history;
11. your allergy;
12. your surgeries;
13. which drugs are you taking;
14. which drugs you are planning to taking
15. high blood pressure;
16. some agreement you must follow (Monitor blood pressure, not take fioricet is pregnant or breast feeding)
17. you must know your responsibility when you take fioricet
18. a lot of other detail about your ED, or nitroglycerin something ..

Our health questionnaires have already designed for all the following questions.You just complete our health questionnaires here, we will complete the form according to your health and medical conditions.

For more detail, please check the pictures:
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When ordering Fioricet (or any prescription medication) online, it’s essential to approach the process carefully, ensuring you’re using a legitimate and reputable source.

While discussing Fioricet with a doctor (either in person or through a telemedicine service), you should provide complete and honest information to ensure safe use of the medication.

Here are the key things to tell your doctor:

1. Your Medical History

  • Liver conditions: Since Fioricet contains acetaminophen, you should inform the doctor if you have any history of liver disease (e.g., cirrhosis, hepatitis) or if you drink alcohol regularly, as this increases the risk of liver damage.
  • Kidney problems: Fioricet can strain the kidneys, so if you have a history of kidney disease or reduced kidney function, it’s important to disclose this.
  • Respiratory issues: Let your doctor know if you have conditions like asthma, COPD, or other breathing problems, as butalbital can cause respiratory depression.
  • History of depression or mental illness: If you have ever been diagnosed with depression, anxiety, bipolar disorder, or have had suicidal thoughts, this information is critical since butalbital can worsen these conditions.
  • History of substance abuse or addiction: Tell the doctor if you have a history of drug or alcohol abuse, as Fioricet contains butalbital, which is a habit-forming barbiturate and could lead to dependency or misuse.
  • Stomach or gastrointestinal issues: Mention if you have a history of ulcers, gastritis, or acid reflux, as Fioricet’s caffeine component can exacerbate these conditions.
  • Allergies: Notify your doctor if you have any known allergies to acetaminophen, butalbital, caffeine, or other medications.

2. Current Medications

  • Over-the-counter (OTC) medications: Inform your doctor if you are taking any other OTC medications, particularly pain relievers or medications containing acetaminophen, to avoid exceeding the recommended daily dose.
  • Prescription medications: Mention all prescription medications you are taking, especially:
    • Blood thinners (e.g., warfarin): Acetaminophen can interact with blood thinners, increasing the risk of bleeding.
    • Opioids, sedatives, or other CNS depressants: Butalbital can enhance the sedative effects of these medications, leading to dangerous drowsiness or respiratory depression.
    • MAO inhibitors (antidepressants): Combining Fioricet with these can cause severe interactions.
    • Benzodiazepines or antidepressants: The sedative effects of butalbital can be heightened when combined with these drugs.
    • Other medications containing caffeine: Mention if you take any caffeine-containing medications or supplements to avoid overstimulation.

3. Frequency of Headaches

  • Provide a detailed account of your headache frequency, duration, and severity. The doctor will need to determine whether your condition justifies a prescription for Fioricet. For example:
    • How many headaches you experience per week or month.
    • How long they last.
    • What triggers your headaches (e.g., stress, tension, lack of sleep).

4. Previous Treatments

  • Tell your doctor what treatments you’ve tried in the past for headaches, including:
    • OTC pain relievers (e.g., ibuprofen, aspirin).
    • Prescription medications for migraines or tension headaches.
    • Alternative therapies (e.g., massage, acupuncture).
  • Explain how effective (or ineffective) these treatments have been for your condition.

5. Caffeine Intake

  • Provide information about your caffeine consumption (e.g., coffee, energy drinks, tea), as Fioricet contains caffeine, and excessive intake can lead to side effects like jitteriness, increased heart rate, or anxiety.

6. Alcohol Consumption

  • Be honest about your alcohol use. Drinking alcohol while taking Fioricet increases the risk of liver damage (due to acetaminophen) and CNS depression (due to butalbital). Let the doctor know how much and how often you drink.

7. Use of Other Headache Medications

  • If you take other medications for headaches, such as triptans for migraines, provide this information, as your doctor will want to avoid drug interactions or overuse of pain relievers, which can lead to rebound headaches.

8. Pregnancy or Breastfeeding

  • Let your doctor know if you are pregnant, planning to become pregnant, or breastfeeding, as Fioricet is generally not recommended in these cases. Butalbital can pass through the placenta and breast milk, potentially harming the baby.

9. Potential for Dependency

  • Discuss any concerns you have about dependence or addiction. Since Fioricet contains butalbital, which can be habit-forming, your doctor needs to know if you’re concerned about becoming reliant on the medication.

10. Any Concerns About Ordering Online

  • If you are ordering Fioricet online, make sure to confirm with the doctor if it is safe and legal to do so. It’s critical that you:
    • Use a legitimate online pharmacy that requires a valid prescription.
    • Avoid unregulated sources that could sell counterfeit or unsafe medications.

Key Points to Discuss with Your Doctor When Ordering Fioricet:

  • Medical history (liver/kidney disease, respiratory issues, mental health, substance abuse).
  • Current medications, including over-the-counter drugs and supplements.
  • Frequency and severity of headaches.
  • Previous treatments tried and their effectiveness.
  • Caffeine and alcohol consumption.
  • Pregnancy or breastfeeding status.
  • Concerns about potential addiction.

By sharing this information, you ensure your doctor can prescribe Fioricet safely and appropriately based on your medical history and current condition.

Fioricet Side Effects

Butalbital, acetaminophen, and caffeine combination is used to relieve symptoms of tension (or muscle contraction) headaches.

Butalbital belongs to the group of medicines called barbiturates. Barbiturates act in the central nervous system (CNS) to produce their effects.

Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time. But acetaminophen may cause other unwanted effects when taken in large doses, including liver damage.

When butalbital is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.

Caffeine is a CNS stimulant that is used with pain relievers to increase their effect. It has also been used for migraine headaches. However, caffeine can also cause physical dependence when it is used for a long time. This may lead to withdrawal (rebound) headaches when you stop taking it.

This medicine is available only with your doctor’s prescription.

This product is available in the following dosage forms:

  • Tablet
  • Capsule
Fioricet Side Effects

Side Effects of Fioricet

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  • Lightheadedness
  • shortness of breath

Incidence not known

  • Abdominal or stomach pain
  • black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • blood in the urine or stools
  • blurred vision
  • change in the frequency of urination or amount of urine
  • chills
  • cough
  • diarrhea
  • difficulty with breathing
  • difficulty with swallowing
  • dizziness
  • drowsiness
  • dry mouth
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • flushed or dry skin
  • fruit-like breath odor
  • hives, itching, or skin rash
  • increased hunger
  • increased thirst
  • increased urination
  • joint or muscle pain
  • loss of appetite
  • nausea or vomiting
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seizures
  • shakiness in the legs, arms, hands, or feet
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sweating
  • swelling of the feet or lower legs
  • tightness in the chest
  • trembling or shaking of the hands or feet
  • troubled breathing
  • unexplained weight loss
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weakness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  • Confusion as to time, place, or person
  • dark urine
  • difficult or painful urination
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fever
  • general feeling of discomfort or illness
  • hallucinations
  • headache
  • holding false beliefs that cannot be changed by fact
  • increased sweating
  • irregular, fast or slow, or shallow breathing
  • light-colored stools
  • loss of appetite
  • pale or blue lips, fingernails, or skin
  • restlessness
  • sudden decrease in the amount of urine
  • sweating
  • trouble sleeping
  • unpleasant breath odor
  • unusual excitement, nervousness, or restlessness
  • vomiting of blood
  • yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Relaxed and calm
  • sleepiness

Incidence not known

  • Anxiety
  • bloated
  • constipation
  • continuing ringing or buzzing or other unexplained noise in the ears
  • depression
  • earache
  • excess air or gas in the stomach or intestines
  • false or unusual sense of well-being
  • full feeling
  • hearing loss
  • heartburn
  • heavy eyelids
  • high energy
  • hot spells
  • hyperventilation
  • irritability
  • numbness
  • pain in the leg
  • passing gas
  • sluggishness
  • stuffy nose
  • tingling sensation

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Butalbital Drug Abuse And Dependence

Abuse And Dependee

Butalbital

Barbiturates may be habit-forming: Tolerance, psychological dependence, and physical dependence may occur especially following prolonged use of high doses of barbiturates. The average daily dose for the barbiturate addict is usually about 1500 mg.

As tolerance to barbiturates develops, the amount needed to maintain the same level of intoxication increases; tolerance to a fatal dosage, however, does not increase more than two-fold. As this occurs, the margin between an intoxication dosage and fatal dosage becomes smaller.

The lethal dose of a barbiturate is far less if alcohol is also ingested. Major withdrawal symptoms (convulsions and delirium) may occur within 16 hours and last up to 5 days after abrupt cessation of these drugs.

Intensity of withdrawal symptoms gradually declines over a period of approximately 15 days.

Treatment of barbiturate dependence consists of cautious and gradual withdrawal of the drug. Barbiturate-dependent patients can be withdrawn by using a number of different withdrawal regimens.

One method involves initiating treatment at the patient’s regular dosage level and gradually decreasing the daily dosage as tolerated by the patient.

The Fioricet ‘High’ and Abuse

The butalbital in Fioricet belongs to a class of drugs called barbiturates, a central nervous system depressant.

Like other barbiturates, it has the potential to cause physical and psychological dependence, which can lead to abuse.

Those who use too much Fioricet may report feeling so relaxed and stress-free that they seek out the drug as a way to get high.

Some describe it as feeling intoxicated. However, users can feel depressed and “crash” once the effects wear off.

Fioricet Side Effects That Make You Stop Taking Fioricet

Certain side effects of Fioricet can be serious and may require you to stop taking the medication immediately and seek medical attention.

Bac Fioricet 123
Bac Fioricet 123

These severe side effects can range from potentially life-threatening conditions to significant health issues. Here are the side effects that may require you to discontinue Fioricet use:

1. Liver Damage or Toxicity (Acetaminophen)

  • Symptoms of liver damage may include:
    • Yellowing of the skin or eyes (jaundice)
    • Dark urine
    • Severe nausea or vomiting
    • Upper right abdominal pain
    • Fatigue or weakness
  • If you experience any of these symptoms, stop taking Fioricet and seek medical attention immediately, as acetaminophen can cause serious liver damage or acute liver failure, particularly at high doses.

2. Allergic Reactions

  • Signs of a severe allergic reaction (anaphylaxis) to any component of Fioricet include:
    • Hives or rash
    • Severe itching or swelling (especially of the face, tongue, or throat)
    • Difficulty breathing
    • Dizziness or fainting
  • If you experience any of these symptoms, stop taking Fioricet and seek emergency medical attention.

3. Severe Drowsiness or Sedation (Butalbital)

  • Butalbital, a barbiturate in Fioricet, can cause significant sedation, drowsiness, and impaired coordination. If you experience extreme drowsiness, confusion, or difficulty waking up, you should stop taking the medication and consult your doctor. These symptoms can increase the risk of accidents or falls, especially in the elderly.

4. Respiratory Depression

  • Butalbital can suppress breathing, especially when taken in higher doses or combined with other CNS depressants like alcohol, opioids, or sedatives. Symptoms of respiratory depression include:
    • Slow or shallow breathing
    • Shortness of breath
    • Bluish tint to lips or skin
    • Extreme drowsiness or difficulty staying awake
  • Respiratory depression is a medical emergency, and you should stop Fioricet and seek immediate medical help if you experience these symptoms.

5. Mental or Mood Changes

  • Fioricet can cause mental health effects like depression, anxiety, or suicidal thoughts in some individuals. If you notice:
    • Severe mood changes
    • Feeling unusually sad or hopeless
    • Suicidal thoughts or behavior
    • Unusual changes in behavior
  • Stop taking Fioricet and contact your healthcare provider right away.

6. Severe Stomach Pain or Gastrointestinal Issues

  • Severe abdominal pain, persistent nausea, vomiting, or diarrhea could be signs of serious gastrointestinal issues or liver problems related to acetaminophen toxicity.
  • If you experience these symptoms, discontinue Fioricet and seek medical advice.

7. Seizures

  • Butalbital can cause seizures in rare cases, particularly when taken in higher doses or in combination with other medications that affect the central nervous system. If you have a seizure or experience tremors, you should stop Fioricet and get medical help immediately.

8. Severe Skin Reactions

  • Some individuals may experience serious skin reactions due to acetaminophen, including conditions like Stevens-Johnson Syndrome (SJS) or toxic epidermal necrolysis (TEN). Symptoms include:
    • Rash or blistering
    • Peeling skin
    • Severe redness or swelling
    • Flu-like symptoms
  • These are medical emergencies, and if you experience any of these symptoms, you should stop taking Fioricet immediately and seek urgent care.

9. Signs of Addiction or Dependency (Butalbital)

  • If you notice that you are becoming dependent on Fioricet, taking more than prescribed, or experiencing withdrawal symptoms (e.g., tremors, anxiety, sweating) when you stop taking it, this could be a sign of butalbital addiction. You should talk to your doctor about discontinuing Fioricet and explore safer alternatives for pain management.

10. Overdose Symptoms

  • Fioricet overdose, particularly from acetaminophen or butalbital, can be life-threatening. Symptoms of overdose include:
    • Severe drowsiness
    • Confusion
    • Nausea or vomiting
    • Slow heart rate
    • Difficulty breathing
    • Seizures
    • Loss of consciousness
  • If overdose is suspected, stop taking Fioricet and seek emergency medical attention immediately.

11. Heart-Related Symptoms (Caffeine)

  • Caffeine can sometimes cause heart-related symptoms, especially if combined with other sources of caffeine. Stop taking Fioricet and seek help if you experience:
    • Fast or irregular heartbeat
    • Chest pain
    • Severe headache or dizziness
    • Tremors

Key Takeaways:

  • Stop Fioricet immediately if you experience signs of liver damage, allergic reactions, respiratory issues, severe sedation, seizures, skin reactions, or mental health changes.
  • Seek medical attention in case of overdose or signs of addiction.
  • Contact a healthcare provider if you have persistent side effects that concern you.

Always discuss with your healthcare provider before stopping Fioricet, especially if you’ve been taking it regularly for an extended period, as it may require a gradual tapering off to avoid withdrawal symptoms.

What is The Main Concerns of Taking Fioricet ?

Taking Fioricet, a combination of butalbital, acetaminophen, and caffeine, comes with several concerns due to the potential risks associated with each of its ingredients.

Bac Fioricet 123
Bac Fioricet 123

Here are the main concerns when taking Fioricet:

1. Risk of Dependence and Abuse (Butalbital)

  • Butalbital, a barbiturate, is a central nervous system (CNS) depressant that can cause drowsiness and relaxation. Over time, this can lead to physical dependence or psychological addiction. Fioricet has a potential for abuse, particularly in those with a history of substance use disorders.
  • Stopping Fioricet abruptly after prolonged use can lead to withdrawal symptoms, including anxiety, tremors, seizures, and agitation.

2. Liver Damage (Acetaminophen)

  • Acetaminophen is generally safe in recommended doses, but taking too much can lead to liver damage or even acute liver failure. The risk is higher if:
    • You take more than the recommended daily dose (no more than 4,000 mg of acetaminophen for adults).
    • You use Fioricet along with other medications that contain acetaminophen (e.g., cold medicines or other pain relievers).
    • You consume alcohol while taking Fioricet, as this significantly increases the risk of liver toxicity.

3. Sedation and Impaired Alertness (Butalbital)

  • Butalbital can cause drowsiness, dizziness, and impaired coordination, making activities like driving, operating machinery, or performing tasks that require full attention dangerous.
  • Combining Fioricet with other CNS depressants (such as benzodiazepines, opioids, or alcohol) can increase the risk of extreme sedation, respiratory depression, or even coma.

4. Rebound Headaches

  • Overuse of Fioricet can lead to medication-overuse headaches (also known as rebound headaches). This occurs when the medication used to treat headaches actually causes them to occur more frequently. Regular use of Fioricet (more than two days per week) increases the risk of developing chronic headaches.

5. Gastrointestinal Issues (Caffeine)

  • The caffeine in Fioricet can cause stomach upset, heartburn, or exacerbate existing gastrointestinal problems like acid reflux or ulcers.
  • Caffeine can also lead to symptoms such as nervousness, jitteriness, increased heart rate, or insomnia, especially if taken in combination with other sources of caffeine (like coffee or energy drinks).

6. Respiratory Depression (Butalbital)

  • Butalbital, as a barbiturate, can cause respiratory depression (slow or shallow breathing), especially at higher doses or when combined with other CNS depressants. This can be life-threatening in severe cases.

7. Risk of Overdose

  • Overdose is a significant concern with Fioricet, especially due to the combined effects of its ingredients:
    • Butalbital overdose can cause excessive sedation, confusion, difficulty breathing, and coma.
    • Acetaminophen overdose can lead to liver failure, which may require a liver transplant or be fatal if not treated promptly.
    • Caffeine overdose can cause restlessness, rapid heartbeat, or tremors.

8. Allergic Reactions

  • Some individuals may experience an allergic reaction to any of the components of Fioricet, particularly acetaminophen. Symptoms may include rash, itching, swelling, dizziness, or trouble breathing. In such cases, medical help should be sought immediately.

9. Potential for Mental Health Effects

  • Butalbital can affect mood, leading to feelings of depression, anxiety, or irritability in some individuals. Long-term use may increase the risk of developing depressive symptoms or even suicidal thoughts.

10. Interactions with Other Medications

  • Fioricet can interact with many other medications, leading to dangerous side effects. For example:
    • Blood thinners (like warfarin): Acetaminophen can increase the risk of bleeding.
    • CNS depressants (like alcohol, opioids, sedatives): Increased risk of excessive sedation and respiratory depression.
    • MAO inhibitors (used to treat depression): Potentially dangerous interactions with butalbital.

11. Effects on Pregnancy and Breastfeeding

  • Fioricet is generally not recommended during pregnancy, especially because butalbital can cross the placenta and may cause neonatal withdrawal syndrome or developmental issues. It can also pass into breast milk and cause side effects in nursing infants.

12. Contraindications in Specific Medical Conditions

  • People with certain health conditions, such as liver disease, kidney disease, respiratory conditions (like asthma or COPD), or porphyria, should not take Fioricet or should do so only under close medical supervision.

Summary of Main Concerns:

  • Dependence and abuse potential (due to butalbital).
  • Liver damage (due to acetaminophen).
  • Impaired alertness and sedation (butalbital).
  • Rebound headaches from overuse.
  • Gastrointestinal issues (from caffeine).
  • Respiratory depression (butalbital).
  • Overdose risk from combined ingredients.
  • Mental health effects (e.g., depression).
  • Dangerous interactions with other medications.

Because of these concerns, Fioricet should be used cautiously, according to prescribed guidelines, and under close medical supervision to minimize risks.

What is The Max Dosage of Acetaminophen ?

The maximum dosage of acetaminophen (also known as paracetamol) depends on the form being used, the individual’s health condition, and whether other medications containing acetaminophen are being taken simultaneously.

Here are the general guidelines for acetaminophen dosing:

1. For Adults (12 years and older)

  • Maximum Single Dose: 1,000 mg (1 gram)
  • Maximum Daily Dose:
    • FDA-recommended maximum: 4,000 mg (4 grams) per day.
    • Some experts recommend limiting the daily dose to 3,000 mg (3 grams) to reduce the risk of liver damage, especially for people with certain risk factors (such as frequent alcohol use or pre-existing liver conditions).

2. For Children (Under 12 years old)

  • The dosage for children depends on their age and weight. Always follow pediatric dosing guidelines or consult a healthcare provider.
  • For example, the typical dosage for children is 10-15 mg/kg of body weight per dose, with a maximum of five doses in 24 hours. The specific dosage should be based on weight rather than age.

3. Factors That Lower the Maximum Dosage

Some individuals may need to take less than 4,000 mg of acetaminophen per day due to increased risk of liver damage. These include:

  • Chronic alcohol users: Alcohol increases the risk of liver damage, and it is recommended that individuals who drink alcohol limit their acetaminophen intake to 2,000 mg (2 grams) per day.
  • People with liver disease: Those with conditions such as hepatitis or cirrhosis should also stick to a lower maximum dose, often no more than 2,000 mg per day, but this should be determined by a doctor.
  • Those taking multiple acetaminophen-containing medications: Many over-the-counter and prescription medications (like cold medications, pain relievers, and combination drugs like Fioricet) contain acetaminophen. Make sure the total daily intake from all sources does not exceed the recommended limit.

4. Risks of Exceeding the Maximum Dosage

Exceeding the recommended dose of acetaminophen can lead to serious liver damage or acute liver failure, which can be fatal. Symptoms of overdose may not appear immediately, but include nausea, vomiting, loss of appetite, and jaundice (yellowing of the skin or eyes).

Key Points:

  • Adults: Do not exceed 4,000 mg of acetaminophen per day.
  • Frequent alcohol users or those with liver conditions should limit intake to 2,000 mg per day.
  • Children: Doses should be based on weight, and consult a doctor for proper guidelines.

Always check medication labels and consult with a healthcare provider if unsure about safe acetaminophen use, especially when taking other medications.

Bac Fioricet 123
Bac Fioricet 123

What Are The Max Dosage of Fioricet ?

Acetaminophen, which is also known as paracetamol, is a commonly used OTC (over-the-counter) pain reliever (analgesic) and fever reducer (antipyretic). People use it for headaches, and minor aches and pain. Liver injury from acetaminophen overdose remains a serious public health problem despite ongoing regulatory and educational efforts over the past several years to improve the safe use of medicines that contain acetaminophen.

Fioricet contains acetaminophen 325 mg per tablet. The max dosage of an adult for acetaminophen goes down from 4000mg to 3000mg per day.

So only acetaminophen, you should not take more than eight tablet fioricet per day. IF you take more than eight fioricet tablet per day, you will hurt your liver.

From tylenol website, they lowered the maximum daily dose for single-ingredient Extra Strength TYLENOL® (acetaminophen) products sold in the U.S. from 8 pills per day (4,000 mg) to 6 pills per day (3,000 mg). The dosing interval has also changed from 2 pills every 4 – 6 hours to 2 pills every 6 hours.

Who Can Not Take Fioricet ?

Fioricet is a combination medication used to treat tension headaches. It contains butalbital (a barbiturate), acetaminophen (a pain reliever), and caffeine (a stimulant).

Bac Fioricet 123
Bac Fioricet 123

While Fioricet can be effective, it’s not suitable for everyone. Here are the groups of people who should not take Fioricet or should take it with caution:

1. People with a History of Substance Abuse

  • Butalbital, a component of Fioricet, is a barbiturate and can be habit-forming, leading to dependence and potential abuse. People with a history of alcohol or drug addiction should avoid this medication due to its addictive potential.

2. Individuals with Liver Disease

  • Fioricet contains acetaminophen, which can cause liver damage, particularly when taken in high doses or with alcohol. People with liver disease or conditions affecting liver function (such as hepatitis or cirrhosis) should avoid Fioricet or use it with extreme caution. Regular use of acetaminophen-containing products can exacerbate liver damage.

3. Those with Severe Kidney Disease

  • Fioricet can also put stress on the kidneys, and people with kidney disease or impaired kidney function may need to avoid it or use it under close supervision from a doctor.

4. Pregnant or Breastfeeding Women

  • Butalbital may pose risks during pregnancy, as it can cross the placenta and affect fetal development, leading to neonatal withdrawal syndrome or other complications. It can also pass into breast milk and may cause drowsiness, irritability, or withdrawal symptoms in nursing infants. Fioricet is generally not recommended during pregnancy or breastfeeding unless specifically advised by a doctor.

5. People with Porphyria

  • Fioricet is contraindicated in people with porphyria, a rare genetic disorder that affects the production of heme, an essential component of hemoglobin. Barbiturates like butalbital can trigger acute attacks in people with this condition.

6. People with Respiratory Issues

  • Butalbital can cause respiratory depression, so people with asthma, COPD, or other respiratory problems should use caution when taking Fioricet. It may exacerbate breathing issues in individuals with already compromised respiratory function.

7. Those Taking Certain Medications

  • Fioricet can interact with many other medications, potentially causing dangerous side effects. Some key medications that should not be mixed with Fioricet include:
    • MAO inhibitors (used for depression): Combining these with butalbital can cause dangerous reactions, including high blood pressure.
    • Blood thinners like warfarin: The acetaminophen in Fioricet can enhance the effects of blood thinners, increasing the risk of bleeding.
    • Sedatives, tranquilizers, or other CNS depressants: The barbiturate in Fioricet can increase the sedative effects of these drugs, leading to extreme drowsiness or respiratory depression.
    • Other acetaminophen-containing medications: Taking additional acetaminophen can increase the risk of liver toxicity.

8. Elderly Individuals

  • Elderly patients may be more sensitive to the side effects of Fioricet, especially the sedative effects of butalbital, which can increase the risk of falls, dizziness, confusion, and respiratory depression.

9. People with a History of Depression or Mental Health Issues

  • Butalbital has central nervous system depressant effects, and in some individuals, it may worsen symptoms of depression or lead to suicidal thoughts. Caution should be taken for those with mood disorders or a history of mental health issues.

10. People with Stomach Ulcers or Gastrointestinal Issues

  • The caffeine component of Fioricet can irritate the stomach lining and worsen symptoms of acid reflux, gastritis, or ulcers. Individuals with gastrointestinal issues should take it with caution.

11. Alcohol Drinkers

  • Fioricet should not be taken with alcohol. The combination of alcohol with butalbital and acetaminophen can increase the risk of liver damage and dangerous central nervous system depression, potentially leading to respiratory failure or coma.

12. People with Allergies to Any of the Ingredients

  • Anyone who has a known allergy or hypersensitivity to butalbital, acetaminophen, caffeine, or other components of Fioricet should avoid this medication.

13. Children

  • Fioricet is not typically recommended for children, especially those under the age of 12, due to the risk of adverse effects, including potential for overdose with acetaminophen and the sedative effects of butalbital.

Important Note:

Always consult a healthcare provider before taking Fioricet, especially if you fall into any of these categories. They can help determine if the benefits outweigh the risks and monitor for potential side effects or interactions.

Fioricet Drug Interaction

Fioricet contains Butalbital, Acetaminophen, and caffeine.  A lot of other pain relievers contain Butalbital, Acetaminophen, and caffeine too.

I can only list some common over the counter medicines that contain Acetaminophen:  Actifed, Alka-Seltzer, Plus Liquid Gels, Anacin, Cepacol, Contac, Coricidin, Dayquil, Dimetapp, Dristan, Excedrin, Feverall …

Some prescriptions that contain acetaminophen are: Ultrace, Fioricet, Oxycodone, Endocet, Tylox …

FioricetInteractionwithothers

You also must know what drugs contain Butalbital:  Bupap, Phrenilin, Tencon, Cephadyn; Fioricet, Esgic, Esgic-Plus; Fioricet with Codeine, Floricet with Codeine, Phrenilin with Caffeine and Codeine; Axotal; Fiorinal, Butalbital Compound, Farbital, Idenal; Fiorinal with Codeine, Fiorinal with Codeine III, Ascomp with Codeine, Fiortal with Codeine.

When you take more than one pain killer, you must read very carefully about their components.  Never exceed the max dosage of acetaminophen and butalbital of all the medicines you are taking.   Normally All the packages sent to you have the drug introduction and doctor names and phone number.  Read the drug introduction very carefully and never share the medicines with your sisters, your brothers,  your parents, or any friends. Always do not let the children touch the medicines.

Please donot drink any alcohol (Ethanol) with your Fioricet Because Ethanol together with acetaminophen will cause serious side effects that affect your liver, and Ethanol together with Butalbital will cause side effects of dizziness, drowsiness.

The effects of one or more of the drugs in Fioricet may enhance the effects of other drugs. These may include:

    • Monoamine oxidase inhibitors (MAOIs), antidepressants including Marplan (isocarboxazid), Nardil (phenelzine), and others
    • Tranquilizers such as chlordiazepoxide (Librium)
    • Sedative-hypnotics, such as prescription sleeping pills
    • General anesthesia drugs

Remember to always tell your doctor about any prescription, non-prescription, over-the-counter (OTC), illegal and recreational drugs, herbal remedies, nutritional and dietary supplements, and all other drugs and treatments you’re taking.

Please don’t take herb while you are taking Fioricet. Even Vitamins will have some interaction with Fioricet.

Be honest to place the current medicines you are taking in the health questionnaire  form. The doctor will check whether you are OK to take Fioricet.  If they think your current drugs or herbs have some interaction with Fioricet, they will phone you to discuss the situation with you. So please always leave us the correct phone number. We will never call you to promote you anything.

Fioricet Interaction

Fioricet Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Riociguat
  • Viloxazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acepromazine
  • Alfentanil
  • Alprazolam
  • Amobarbital
  • Anileridine
  • Anisindione
  • Aprobarbital
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Asenapine
  • Baclofen
  • Benperidol
  • Bentazepam
  • Benzhydrocodone
  • Bromazepam
  • Buprenorphine
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Calcium Oxybate
  • Cannabidiol
  • Cannabis
  • Capmatinib
  • Carbamazepine
  • Carbinoxamine
  • Carisoprodol
  • Carphenazine
  • Cetirizine
  • Chloral Hydrate
  • Chlordiazepoxide
  • Chlorpromazine
  • Chlorzoxazone
  • Clobazam
  • Clonazepam
  • Clorazepate
  • Cloxazolam
  • Clozapine
  • Codeine
  • Cyclobenzaprine
  • Dantrolene

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acenocoumarol
  • Fosphenytoin
  • Lixisenatide
  • Ospemifene
  • Phenytoin
  • Prednisone
  • St John’s Wort
  • Warfarin
  • Zidovudine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

    • Ethanol
    • Tobacco

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

    • Cabbage

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

    • Alcohol abuse, history of or
    • Drug dependence, or history of or
    • Weakened physical condition—Use with caution. May increase risk for more serious side effects.
    • Kidney disease or
    • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
    • Porphyria (an enzyme problem)—Should not be used in patients with this condition.
    • Stomach problems—Use with caution. May make these conditions worse.

 

The list of FDA Approved Fioricet Manufactures

Fioricet contains a combination of acetaminophen, butalbital, and caffeine.

Each tablet contains the following active ingredients:
butalbital USP . . . . . . . . . . . .50 mg
acetaminophen USP . . . . . . 325 mg
caffeine USP . . . . . . . . . . . . .40 mg

Acetaminophen is a pain reliever and fever reducer.

fioricetButalbital is in a group of drugs called barbiturates. It relaxes muscle contractions involved in a tension headache.

Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.

Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervous system (CNS) depression that ranges from mild sedation to general anesthesia.

Butalbital has a low degree of selectivity and a narrow therapeutic index.1 Typically indicated to manage tension (or muscle contraction) headaches, butalbital is often combined with one or more therapeutic agents, such as acetylsalicylic acid, acetaminophen, aspirin, and caffeine. There have not been clinical trials that evaluate the clinical efficacy of butalbital in migraines  thus it is not indicated for such condition.

As with other barbiturates, butalbital carries a risk of abuse or misuse potential, intoxication, hangover, tolerance, dependence, and overdosage possibly leading to death.

Butalbital?containing analgesics can also produce a drug?induced headache in addition to tolerance and dependence. Due to these risks, the use of butalbital-containing combination products is typically limited for use only in cases where other medications are deemed ineffective and such usage is advised to be carefully monitored.

Fioricet is used to treat tension headaches that are caused by muscle contractions. Fioricet is manufactured by several manufacturers. Fioricet is not controlled substance.

Fioricet Packagers

      • Atley Pharmaceuticals
      • Cardinal Health
      • Chattem Chemicals Inc.
      • D.M. Graham Laboratories Inc.
      • Diversified Healthcare Services Inc.
      • ECR Pharmaceuticals
      • Everett Laboratories Inc.
      • Innoviant Pharmacy Inc.
      • International Ethical Labs Inc.
      • Ivax Pharmaceuticals
      • Marnel Pharmaceuticals Inc.
      • MCR American Pharmaceuticals Inc.
      • Medisca Inc.
      • Merz Pharmaceuticals LLC
      • Mikart Inc.
      • Nucare Pharmaceuticals Inc.
      • PD-Rx Pharmaceuticals Inc.
      • Physicians Total Care Inc.
      • Qualitest
      • Savage Labs
      • Southwood Pharmaceuticals
      • Stat Rx Usa
      • Va Cmop Dallas
      • Valeant Ltd.
      • West-Ward Pharmaceuticals

Fioricet (Butalbital, Acetaminophen and Caffeine ) is produced by following companies:

List as:

company name – Trade Name – NDC code – Form – controlled substance – controlled substance dosage(mg)

Actavis Pharma, Inc.   Butalbital, Acetaminophen and Caffeine Capsules USP 50/300/40 0591-2640 CA Butalbital 50.00
Actavis Pharma, Inc. Butalbital, Acetaminophen and Caffeine Tablets USP 50/325/40 0591-3369 TB Butalbital 50.00
Actavis Pharma, Inc. Fioricet (Butalbital, Acetaminophen and Caffeine USP 50/300/40) 52544-080 CA Butalbital 50.00

Alphagen Laboratories, Inc.  Butalbital and Acetaminophen Capsules 50mg/ 650mg 00603-2542 CA Butalbital 50.00

Althon Pharmaceuticals, Inc.  Butalbital, Acetaminophen and Caffeine Tablets USP 66813-074 TB Butalbital 50.00
Alvogen, Inc. Butalbital and AcetaminophenTablets USP 50/325 47781-0535 CA Butalbital 50.00
Alvogen, Inc. Butalbital, Acetaminophen and Caffeine Tablets USP 50/325/40 47781-0536 CA Butalbital 50.00

Amerisource Health Services Corporation  Butalbital, Acetaminophen and Caffeine Tablets 50/325/40mg 68084-0396 TB Butalbital 50.00

Atley Pharmaceuticals  Butalbital, Acetaminophen and Caffeine Tablets 59702-661 TB Butalbital 50.00
AvKare, Inc. Butalbital, Acetaminophen and Caffeine Tablets USP 50/325/40 50268-139 TB Butalbital 50.00
AvKare, Inc. Butalbital, Acetaminophen and Caffeine Capsules USP 50/300/40 42291-181 CA Butalbital 50.00

Cardinal Health  Butalbital, Acetaminophen and Caffeine Tablets 50mg/325mg/40mg 0904-6538 TB Butalbital 50.00

D.M. Graham Laboratories, Inc.  Butalbital, Acetaminophen and Caffeine Tablets 00756-0111 TB Butalbital 50.00

Duramed Pharmaceuticals  Butalbital, Acetaminophen and Caffeine Tablets 51285-0849 TB Butalbital 50.00

Forest Pharmacal Inc  Acetaminophen 325 mg/Butalbital 50 mg 00456-0674 TB Butalbital 50.00
Forest Pharmacal Inc  Acetaminophen 500 mg/Butalbital 50 mg 00456-0671 TB Butalbital 50.00

Geneva Pharmaceuticals, Inc.  Butalbital, Acetaminophen and Caffeine Tablets 00781-1901 TB Butalbital 50.00

Halsey Drug Co Inc  Blue Cross Butalbital, APAP and Caffeine Tablets 00879-0567 TB Butalbital 50.00
Halsey Drug Co Inc Butalbital and Acetaminophen Tablets 00879-0543 TB Butalbital 50.00

Inwood Laboratories, Inc.  Butalbital, Acetaminophen and Caffeine Tablets, USP 0258-3657 TB Butalbital 50.00

Lannett Company, Inc.  Butalbital, Acetaminophen & Caffeine Tablets (50mg/325mg/40mg) 00527-1695 TB Butalbital 50.00

Lemmon Company  Acetaminophen/Butalbital/Caffeine Tablets 00093-0854 TB Butalbital 50.00

Libertas Pharma, Inc.  Butalbital, Acetaminophen and Caffeine Capsules USP 51862-179 CA Butalbital 50.00

Mallinckrodt Inc.  Butalbital, Acetaminophen, and Caffeine (“BAC”) Tablets USP 00406-0970 TB Butalbital 50.00

Martec Pharmacal Inc  Butalbital, Acetaminophen and Caffeine Tablets 52555-0079 TB Butalbital 50.00

Midlothian Laboratories (Manufactured by Mikart, Inc.) Esgic (Butalbital, Acetaminophen, & Caffeine Capsules 50/325/40 68308-219 CA Butalbital 50.00
Midlothian Laboratories (Manufactured by Mikart, Inc.) Esgic (Butalbital, Acetaminophen, & Caffeine Tablets 50/325/40 68308-220 TB Butalbital 50.00
Midlothian Laboratories (Manufactured by Mikart, Inc.) Zebutal (Butalbital, Acetaminophen, & Caffeine Capsules 50/325/40 68308-554 CA Butalbital 50.00

Mikart FIoricet

Mikart, Inc.  Butalbital and Acetaminophen Tablets 50/325 46672-0099 TB Butalbital 50.00
Mikart, Inc. Butalbital and Acetaminophen Tablets 50/650 11584-0029 TB Butalbital 50.00
Mikart, Inc. Butalbital and Acetaminophen Tablets 50/650 46672-0098 TB Butalbital 50.00
Mikart, Inc. Butalbital, Acetaminophen and Caffeine Capsules 46672-0228 CA Butalbital 50.00
Mikart, Inc. Butalbital, Acetaminophen and Caffeine Capsules 00588-7788 CA Butalbital 50.00
Mikart, Inc. Butalbital, Acetaminophen and Caffeine Eilixer 46672-0633 EL Butalbital 50.00
Mikart, Inc. Butalbital, Acetaminophen and Caffeine Tablets 52555-0647 TB Butalbital 50.00
Mikart, Inc. Butalbital, Acetaminophen and Caffeine Tablets 46672-0053 TB Butalbital 50.00
Mikart, Inc. Butalbital, Acetaminophen and Caffeine Tablets USP 49884-0811 TB Butalbital 50.00
Mikart, Inc. Butalbital, Acetaminophen and Caffeine Tablets USP 00258-3665 TB Butalbital 50.00
Mikart, Inc. Butalbital, Acetaminophen and Caffeine Tablets USP (50/325/40) 51862-540 TB Butalbital 50.00
Mikart, Inc. Butalbital, Acetaminophen and Caffeine Tablets, USP 0591-3416 TB Butalbital 50.00

Mikart, Inc. Butalbital and Acetaminophen Tablets 50/300 46672-286 TB Butalbital 50.00
Mikart, Inc. Butalbital and Acetaminophen Tablets 50/300 46672-856 TB Butalbital 50.00
Mikart, Inc. Butalbital, Acetaminophen and Caffeine Tablets, USP 46672-184 TB Butalbital 50.00
Mikart, Inc. Butalbital, Acetaminophen, and Caffeine Oral Solution 66813-073 LQ Butalbital 50.00
Mikart, Inc. Butalbital, Acetaminophen, and Caffeine Tablets 51432-0034 TB Butalbital 50.00
Mikart, Inc. Butalbital, Acetaminophen, and Caffeine Tablets 46672-0059 TB Butalbital 50.00

Mikart, Inc. Esgic Capsules 00535-0012 CA Butalbital 50.00
Mikart, Inc. Esgic Tablets 00535-0011 TB Butalbital 50.00

Mikart, Inc. (on behalf of Mayne Pharma) Butalbital and Acetaminophen Tablets 50/300 51862-538 TB Butalbital 50.00

Moore Medical Corporation  Butalbital, Acetaminophen and Caffeine Tablets 00839-7831 TB Butalbital 50.00

Nexgen Pharma  BUPAP (Butalbital and Acetaminophen 50mg/300mg) 0095-3000 TB Butalbital 50.00
Nexgen Pharma Butalbital with Acetaminophen and Caffeine Tablets 0722-7029 CA Butalbital 50.0

Oceanside Pharmaceuticals (Manufactured by Nexgen) Butalbital and Acetaminophen Tablets (50mg/300mg) 68682-306 TB Butalbital 50.00

PD-Rx Pharmaceuticals, Inc.  Butalbital/APAP/Caffeine Tablets (50mg/325mg/40mg) 55289-0879 TB Butalbital 50.00

Pharmaceutical Basics Inc Butalbital, Acetaminophen and Caffeine Tablets 00832-1102 TB Butalbital 50.00

Qualitest Pharmaceuticals, Inc.  Butalbital and Acetaminophen Tablets 0603-2540 TB Butalbital 50.00
Qualitest Pharmaceuticals, Inc. Butalbital, Acetaminophen and Caffeine Tablets 50/325/40mg 0603-2544 TB Butalbital 50.00
Qualitest Pharmaceuticals, Inc. Butalbital, Acetaminophen and Caffeine Tablets USP 0603-2547 TB Butalbital 50.00
Qualitest Pharmaceuticals, Inc. Butalbital, Acetaminophen and Caffeine Tablets, USP 0603-2551 TB Butalbital 50.00

Qualitest Products Inc Butalbital, Acetaminophen and Caffeine Tablets 52446-0544 TB Butalbital 50.00

Rugby Laboratories Inc  Butalbital, Acetaminophen and Caffeine Tablets, USP 0536-5567 TB Butalbital 50.00

Sunrise Pharmaceuticals, Inc.  Butalbital, Acetaminophen, Caffeine Capsules (50 mg/300 mg/40mg) 11534-187 CA Butalbital 50.00

Tedor Pharma, Inc. (Manufactured for Xspire Pharma) Butalbital, Acetaminophen and Caffeine Caps (50mg/300mg/40mg) 42195-955 CA Butalbital 50.00

West-Ward Pharmaceutical Corp. Butalbital with Acetaminophen and Caffeine Tablets 00143-1787 TB Butalbital 50.00
West-Ward Pharmaceutical Corp. Butalbital, Acetaminophen and Caffein Capsules 00143-3001 CA Butalbital 50.00

West-Ward Pharmaceutical Corp. Butalbital, Acetaminophen, and Caffeine Tablets, USP 00143-1115 TB Butalbital 50.00

Zenith Goldline Pharmaceuticals Butalbital, Acetaminophen and Caffeine Tablets 00182-2659 TB Butalbital 50.00

You can also check the Fioricet Manufacturers here in DEA Websites.

 

Fioricet Storage and Fioricet Interactions

Fioricet Storage

  • Keep out of the reach of children since overdose is especially dangerous in children.
  • Store away from heat and direct light.
  • Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
  • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

How do I take Fioricet?

Fioricet should be taken exactly as prescribed by your physician. Do not take it in larger amounts or for longer than recommended. Follow the directions on your fioricet prescription label and tell your physician if the medicine seems to stop working as well in relieving your pain.  If Fioricet upsets your stomach take it with food or milk. An overdose of acetaminophen can cause serious harm and damage to your liver. The maximum amount of acetaminophen for an adult is 1 gram per dose and 4 grams per day. Taking more acetaminophen could cause damage to your liver.

Fioricet Interactions with other prescriptions

Fioricet Interaction with other drugs
Fioricet Interaction with other drugs

Taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking Fioricet with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may interact with acetaminophen, butalbital, and caffeine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

    • Riociguat

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

      • Alfentanil
      • Alprazolam
      • Amobarbital
      • Anisindione
      • Aprobarbital
      • Butabarbital
      • Carisoprodol
      • Chloral Hydrate
      • Chlordiazepoxide
      • Chlorzoxazone
      • Clarithromycin
      • Clonazepam
      • Clorazepate
      • Dantrolene
      • Darunavir
      • Diazepam
      • Dicumarol
      • Doxorubicin
      • Doxorubicin Hydrochloride Liposome
      • Esketamine
      • Estazolam
      • Ethchlorvynol
      • Etonogestrel
      • Flunitrazepam
      • Flurazepam
      • Halazepam
      • Imatinib
      • Iobenguane I 131
      • Isoniazid
      • Ketazolam
      • Lorazepam
      • Lormetazepam
      • Medazepam
      • Mephenesin
      • Mephobarbital
      • Meprobamate
      • Metaxalone
      • Methocarbamol
      • Methohexital
      • Midazolam
      • Nifedipine
      • Nitrazepam
      • Oxazepam
      • Peginterferon Alfa-2b
      • Pentobarbital
      • Phenindione
      • Phenobarbital
      • Phenprocoumon
      • Piperaquine
      • Pixantrone
      • Pneumococcal 13-Valent Vaccine, Diphtheria Conjugate
      • Prazepam
      • Primidone
      • Quazepam
      • Secobarbital
      • Sodium Oxybate
      • Temazepam
      • Thiopental
      • Trazodone
      • Triazolam
      • Ulipristal

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

      • Acenocoumarol
      • Cannabis
      • Carbamazepine
      • Fosphenytoin
      • Lixisenatide
      • Ospemifene
      • Phenytoin
      • Prednisone
      • Warfarin
      • Zidovudine

The Mechanism of Action of Fioricet

The roles and interactions of the combination of acetaminophen, butalbital and caffeine in the treatment of tension headaches are not well understood. But the different mechanisms of action of acetaminophen, or butalbital, or caffeine are well understood.

The mechanism of action of acetaminophen

The mechanisms of action of acetaminophenAcetaminophen:  Acetaminophen acts primarily in the CNS and increases the pain threshold by inhibiting cyclooxygenase, an enzyme involved in prostaglandin (PG) synthesis. Paracetamol (acetaminophen) is generally considered to be a weak inhibitor of the synthesis of prostaglandins (PGs). However, the in vivo effects of paracetamol are similar to those of the selective cyclooxygenase-2 (COX-2) inhibitors. Paracetamol also decreases PG concentrations in vivo, but, unlike the selective COX-2 inhibitors, paracetamol does not suppress the inflammation of rheumatoid arthritis.  Acetaminophen inhibits both isoforms of central cyclooxygenase, COX-1 and COX-2.

Acetaminophen does not inhibit PG synthesis in peripheral tissues, which is the reason for its lack of peripheral anti-inflammatory effects. The antipyretic activity of acetaminophen is exerted by blocking the effects of endogenous pyrogen on the hypothalamic heat-regulating center by inhibiting PG synthesis. Heat is dissipated by vasodilatation, increased peripheral blood flow, and sweating.

The mechanism of action of butalbital

Butalbital (5-allyl-5-isobutylbarbituric acid), a slightly bitter, white, odorless, crystalline powder, is a short to intermediate-acting barbiturate. The mechanism of action of barbiturate is listed below:

The mechanism of action of barbiturate

 

Butalbital:  Butalbital has generalized depressant effect on central nervous system and, in very high doses, has peripheral effects. Sedative-hypnotic effects of butalbital are similar to phenobarbital and may result from producing or enhancing the inhibitory affects of gamma-aminobutyric acid (GABA) in the thalamus. Barbiturates inhibit ascending conduction in the reticular formation, which interferes with conduction of impulses to the cortex causing sensory cortex depression, decreased motor activity, drowsiness, sedation and changes in cerebral function. Barbiturates also cause a nonselective depressant effect throughout the CNS and are capable of producing all types of CNS mood alterations. In addition, butalbital may exhibit anticonvulsant affects in high, anesthetic doses.

The mechanism of action of Caffeine

The mechanism of action of caffeine

Caffeine is thought to produce constriction of cerebral blood vessels and serves to counteract the sedative effect of butalbital.  Caffeine causes cerebral vasoconstriction, which decreases blood flow and oxygen tension. In combination with acetaminophen, caffeine may provide a quicker onset of action and enhance pain relief allowing for lower doses of analgesics. In some patients, caffeine relieves headaches by treating the effects of caffeine withdrawal.

Butalbital has a half-life of about 35 hours. Acetaminophen has a half-life of about 1.25 to 3 hours, but may be increased by liver damage and after an overdose. Caffeine has a half-life of about 2.5 to 4.5 hours.